This Technical Report presents results from a large set of sectoral impact models that quantify and monetize climate change impacts in the U.S., with a primary focus on the contiguous U.S., under moderate and severe future climates. The report summarizes and communicates the results of the second phase of quantitative sectoral impacts analysis under the Climate Change Impacts and Risk Analysis (CIRA) project. The effort is intended to inform the fourth National Climate Assessment (NCA4) of the U.S. Global Change Research Program (USGCRP). The goal of this work is to estimate climate change impacts and economic damages to multiple U.S. sectors (e.g., human health, infrastructure, and water resources) under different scenarios. Though this report does not make policy recommendations, it is designed to inform strategies to enhance resiliency and protect human health, investments, and livelihoods.